Article

Bace1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

2022-09-20

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>: Abnormal accumulation of amyloid beta peptide (Aβ) in the brain induces a cascade of pathological changes in Alzheimer’s disease (AD), and inhibiting BACE1 to reduce Aβ production is therefore being explored for the treatment of AD. Here we investigated the role of BACE1 in astrocytes as <italic>Bace1</italic>knockout mice exhibit increased number of reactive as...

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Literature Corpus work: 9237c329-1c8a-5a6d-a09b-a557a886c96c
DOI: 10.21203/rs.3.rs-2042855/v1

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