Article

Oligodendrocytes show enriched expression of amyloid precursor protein and GABA B receptor isoform 1a

2025-11-29

Abstract excerpt

Amyloid precursor protein (APP) is a type I transmembrane protein that undergoes proteolytic processing to generate amyloid-β, the main component of amyloid plaques found in brains with Alzheimer’s disease. The proteolytic processing of APP also generates soluble APP alpha (sAPPα) which can modulate synaptic transmission and neurite outgrowth through the γ-aminobutyric acid type B receptor (GABA B R). Whether GAB...

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Literature Corpus work: 269c18b2-388b-5d05-b14e-6b39ffd78c35
DOI: 10.1101/2025.11.25.690528

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