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High-risk Molecular Features Eclipse Genomic Complexity in Predicting CLL Patient Outcomes; Insights from the UK CLL4, ARCTIC and ADMIRE Trials

2025-07-22

Abstract excerpt

High genomic complexity is linked to poor prognosis in chronic lymphocytic leukaemia (CLL), but its independent prognostic value remains uncertain amid emerging biomarkers. We analysed copy number alterations (CNA) in 495 treatment-naïve patients from three randomized trials (CLL4, ADMIRE, ARCTIC), incorporating IGHV status, telomere length (TL), targeted sequencing, and DNA-methylation subtypes. Patients harboure...

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Literature Corpus work
92244c8a-634a-5d3f-8886-b4a1ac240ef7
DOI
10.1101/2025.07.22.25331923
Open publication

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High-risk Molecular Features Eclipse Genomic Complexity in Predicting CLL Patient Outcomes; Insights from the UK CLL4, ARCTIC and ADMIRE TrialsDOI 10.1101/2025.07.22.25331923
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