Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features.

doi:10.1038/s41588-022-01211-y

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Article

Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features.

Nature genetics - 1 Nov 2022

Robbe Pauline, Ridout Kate E, Vavoulis Dimitrios V, Dréau Helene, Kinnersley Ben, Denny Nicholas, Chubb Daniel, Appleby Niamh, Cutts Anthony, Cornish Alex J, Lopez-Pascua Laura, Clifford Ruth, Burns Adam, Stamatopoulos Basile, Cabes Maite, Alsolami Reem, Antoniou Pavlos, Oates Melanie, Cavalieri Doriane, Gibson Jane, Prabhu Anika V, Schwessinger Ron, Jennings Daisy, James Terena, Maheswari Uma, Duran-Ferrer Martí, Carninci Piero, Knight Samantha J L, Månsson Robert, Hughes Jim, Davies James, Ross Mark, Bentley David, Strefford Jonathan C, Devereux Stephen, Pettitt Andrew R, Hillmen Peter, Caulfield Mark J, Houlston Richard S, Martín-Subero José I, Schuh Anna

Abstract excerpt

The value of genome-wide over targeted driver analyses for predicting clinical outcomes of cancer patients is debated. Here, we report the whole-genome sequencing of 485 chronic lymphocytic leukemia patients enrolled in clinical trials as part of the United Kingdom's 100,000 Genomes Project. We identify an extended catalog of recurrent coding and noncoding genetic mutations that represents a source for future...

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PMID: 36333502
DOI: 10.1038/s41588-022-01211-y
PMCID: PMC9649442

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