Article
Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia.
Nature communications - 13 Sept 2021
Bloehdorn Johannes, Braun Andrejs, Taylor-Weiner Amaro, Jebaraj Billy Michael Chelliah, Robrecht Sandra, Krzykalla Julia, Pan Heng, Giza Adam, Akylzhanova Gulnara, Holzmann Karlheinz, Scheffold Annika, Johnston Harvey E, Yeh Ru-Fang, Klymenko Tetyana, Tausch Eugen, Eichhorst Barbara, Bullinger Lars, Fischer Kirsten, Weisser Martin, Robak Tadeusz, Schneider Christof, Gribben John, Dahal Lekh N, Carter Mathew J, Elemento Olivier, Landau Dan A, Neuberg Donna S, Cragg Mark S, Benner Axel, Hallek Michael, Wu Catherine J, Döhner Hartmut, Stilgenbauer Stephan, Mertens Daniel
Abstract excerpt
Knowledge of the genomic landscape of chronic lymphocytic leukemia (CLL) grows increasingly detailed, providing challenges in contextualizing the accumulated information. To define the underlying networks, we here perform a multi-platform molecular characterization. We identify major subgroups characterized by genomic instability (GI) or activation of epithelial-mesenchymal-transition (EMT)-like programs, which...
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