Article
The complex karyotype landscape in chronic lymphocytic leukemia allows the refinement of the risk of Richter syndrome transformation.
Haematologica - 1 Apr 2022
Visentin Andrea, Bonaldi Laura, Rigolin Gian Matteo, Mauro Francesca Romana, Martines Annalisa, Frezzato Federica, Pravato Stefano, Gargarella Leila Romano, Bardi Maria Antonella, Cavallari Maurizio, Volta Eleonora, Cavazzini Francesco, Nanni Mauro, Facco Monica, Piazza Francesco, Guarini Anna, Foà Robin, Semenzato Gianpietro, Cuneo Antonio, Trentin Livio
Abstract excerpt
Complex karyotype (CK) at chronic lymphocytic leukemia (CLL) diagnosis is a negative biomarker of adverse outcome. Since the impact of CK and its subtypes, namely type-2 CK (CK with major structural abnormalities) or high-CK (CK with ≥5 chromosome abnormalities), on the risk of developing Richter syndrome (RS) is unknown, we carried out a multicenter real-life retrospective study to test its prognostic impact....
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