Article
Clinical impact of the subclonal architecture and mutational complexity in chronic lymphocytic leukemia.
Leukemia - 1 Mar 2018
Nadeu F, Clot G, Delgado J, Martín-García D, Baumann T, Salaverria I, Beà S, Pinyol M, Jares P, Navarro A, Suárez-Cisneros H, Aymerich M, Rozman M, Villamor N, Colomer D, González M, Alcoceba M, Terol M J, Navarro B, Colado E, Payer Á R, Puente X S, López-Otín C, López-Guillermo A, Enjuanes A, Campo E
Abstract excerpt
Genome studies of chronic lymphocytic leukemia (CLL) have revealed the remarkable subclonal heterogeneity of the tumors, but the clinical implications of this phenomenon are not well known. We assessed the mutational status of 28 CLL driver genes by deep-targeted next-generation sequencing and copy number alterations (CNA) in 406 previously untreated patients and 48 sequential samples. We detected small subclonal...
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