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Article

Integrative NGS testing reveals clonal dynamics of adverse genomic defects contributing to a natural progression in treatment-naïve CLL patients.

British journal of haematology - 1 Jan 2024

Navrkalova Veronika, Plevova Karla, Radova Lenka, Porc Jakub, Pal Karol, Malcikova Jitka, Pavlova Sarka, Doubek Michael, Panovska Anna, Kotaskova Jana, Pospisilova Sarka

Abstract excerpt

Large-scale next-generation sequencing (NGS) studies revealed extensive genetic heterogeneity, driving a highly variable clinical course of chronic lymphocytic leukaemia (CLL). The evolution of subclonal populations contributes to diverse therapy responses and disease refractoriness. Besides, the dynamics and impact of subpopulations before therapy initiation are not well understood. We examined changes in...

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PMID: 38062779
DOI: 10.1111/bjh.19191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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