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Article

Molecular genetics of high-risk chronic lymphocytic leukemia.

Expert review of hematology - 1 Dec 2012

Rossi Davide, Gaidano Gianluca

Abstract excerpt

In an optimized management algorithm of chronic lymphocytic leukemia (CLL), the early identification of high-risk patients, ideally prior to treatment, is a prerequisite for designing strategies tailored at overcoming therapy resistance. TP53 abnormalities play a central role in our current understanding of the poor prognosis of high-risk CLL patients, but fail to explain the molecular basis of 50% of high-risk...

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Share to NOTCH1 gene
Share to Inhibitor of Apoptosis Proteins
Share to Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Tumor Suppressor Protein p53

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Source

Identifiers

PMID: 23216591
DOI: 10.1586/ehm.12.58

Genes

NOTCH1

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