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Article

Steroid hormones sulfatase inactivation extends lifespan and ameliorates age-related diseases.

Nature communications - 4 Jan 2021

Pérez-Jiménez Mercedes M, Monje-Moreno José M, Brokate-Llanos Ana María, Venegas-Calerón Mónica, Sánchez-García Alicia, Sansigre Paula, Valladares Amador, Esteban-García Sara, Suárez-Pereira Irene, Vitorica Javier, Ríos José Julián, Artal-Sanz Marta, Carrión Ángel M, Muñoz Manuel J

Abstract excerpt

Aging and fertility are two interconnected processes. From invertebrates to mammals, absence of the germline increases longevity. Here we show that loss of function of sul-2, the Caenorhabditis elegans steroid sulfatase (STS), raises the pool of sulfated steroid hormones, increases longevity and ameliorates protein aggregation diseases. This increased longevity requires factors involved in germline-mediated...

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Identifiers

PMID: 33397961
DOI: 10.1038/s41467-020-20269-y
PMCID: PMC7782729

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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