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Article

Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans.

Scientific reports - 1 Jan 2012

Honda Yoko, Higashibata Akira, Matsunaga Yohei, Yonezawa Yukiko, Kawano Tsuyoshi, Higashitani Atsushi, Kuriyama Kana, Shimazu Toru, Tanaka Masashi, Szewczyk Nathaniel J, Ishioka Noriaki, Honda Shuji

Abstract excerpt

How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically expressed polyglutamine aggregates, which normally accumulate with increasing age. Moreover, the inactivation of each of seven genes that were down-regulated in space extended lifespan on the ground. These genes encode proteins that are...

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PMID: 22768380
DOI: 10.1038/srep00487
PMCID: PMC3390002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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