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Article

Replenishment of TCA cycle intermediates provides photoreceptor resilience against neurodegeneration during progression of retinitis pigmentosa.

JCI insight - 8 Sept 2021

Rowe Ashley A, Patel Pinkal D, Gordillo Ruth, Wert Katherine J

Abstract excerpt

The metabolic environment is important for neuronal cells, such as photoreceptors. When photoreceptors undergo degeneration, as occurs during retinitis pigmentosa (RP), patients have progressive loss of vision that proceeds to full blindness. Currently, there are no available treatments for the majority of RP diseases. We performed metabolic profiling of the neural retina in a preclinical model of RP and found...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34292885
DOI: 10.1172/jci.insight.150898
PMCID: PMC8492344

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