Article

BDH1-Dependent Ketone Body Metabolism Maintains Müller Cell Homeostasis and Retinal Function

2025-12-27

Abstract excerpt

Ketone body metabolism serves as an auxiliary regulator of cellular energetics and redox balance, particularly during prolonged fasting and carbohydrate restriction, yet its role in retinal homeostasis under physiological conditions remains poorly defined. β-hydroxybutyrate dehydrogenase 1 (BDH1) is a mitochondrial enzyme that interconverts acetoacetate and β-hydroxybutyrate, and is required for efficient ketone u...

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Literature Corpus work: 8c06f66e-14e8-5fef-9d9d-9b912dca8829
DOI: 10.64898/2025.12.27.696636

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