Article

Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas

2025-02-19

Abstract excerpt

Spontaneous transdifferentiation of pancreatic glucagon-producing alpha to insulin-secreting beta-cells has been observed in mouse but not in human islets 1 . Here, we analyzed the largest single-cell dataset of human islets to date, composed of 650,000 cells across 121 deceased organ donors, in search of transitional cell states. By integrating single-cell RNA-seq, single-nucleus ATAC-seq and single-nucleus mult...

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Literature Corpus work: 6b98ff0b-aee4-584c-aa07-9bc500c29f57
DOI: 10.1101/2025.02.14.638309

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