Article

Signatures of Electron-hole Hopping in Myoglobin Peroxidase Activity Revealed by Deep Mutational Learning

2025-08-31

Abstract excerpt

In addition to storing molecular oxygen, myoglobin catalyzes peroxidase-like reactions involving high valency iron(IV)-oxo species that support one-electron oxidations on a range of substrates at an open active site. In select metalloenzymes, long-range electron transfer can be mediated by hole-hopping pathways composed of aromatic residues that act as relay stations for oxidative equivalents. However, it remains...

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Literature Corpus work: 6e2ce728-61fb-5e1c-a6de-a50b30619378
DOI: 10.1101/2025.08.27.672588

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