Article

MetalPrognosis: a Biological Language Model-based Approach for Disease-Associated Mutations in Metal-Binding Site prediction

2023-11-04

Abstract excerpt

Protein-metal ion interactions play a central role in the onset of numerous diseases. When amino acid changes lead to missense mutations in metal-binding sites, the disrupted interaction with metal ions can compromise protein function, potentially causing severe human ailments. Identifying these disease-associated mutation sites within metal-binding regions is paramount for understanding protein function and foste...

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Literature Corpus work: d20a9dad-3c0c-5b0c-9438-390be63c2114
DOI: 10.1101/2023.11.01.565246

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