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mCSM-metal: A Deep Learning Resource to Predict Effect of Mutations on Metal Ion Binding.

Journal of molecular biology - 15 Sept 2026

Kumar Akshita, Malik Ashar J, Ascher David B

Abstract excerpt

Metal ions play critical structural, regulatory, and enzymatic roles in proteins, making their binding essential for biological processes. Experimental identification of metal-binding sites is resource-intensive and limited in scalability. Recent advances in protein language models have transformed computational predictions, yet current tools do not address how residue-level metal-binding probabilities change...

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PMID: 41651016
DOI: 10.1016/j.jmb.2026.169678

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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