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Nickel import and export in the human pathogenHelicobacter pylori, perspectives from molecular modelling

11 Nov 2021

Abstract excerpt

The uptake of essential metal ions and the ability to extrude them when their excess causes toxicity are crucial processes for all living beings. Nickel is a virulence factor for several human pathogens and in particular for the human gastric pathogen Helicobacter pylori because of its crucial role in the catalytic activity of two Ni-dependent enzymes, urease and hydrogenase. H. pylori requires efficient uptake...

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PMID: 34791340
DOI: 10.1093/mtomcs/mfab066

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