Article
Key Structural Motifs Balance Metal Binding and Oxidative Reactivity in a Heterobimetallic Mn/Fe Protein.
Journal of the American Chemical Society - 18 Mar 2020
Kisgeropoulos Effie C, Griese Julia J, Smith Zachary R, Branca Rui M M, Schneider Camille R, Högbom Martin, Shafaat Hannah S
Abstract excerpt
Heterobimetallic Mn/Fe proteins represent a new cofactor paradigm in bioinorganic chemistry and pose countless outstanding questions. The assembly of the active site defies common chemical convention by contradicting the Irving-Williams series, while the scope of reactivity remains unexplored. In this work, the assembly and C-H bond activation process in the Mn/Fe R2-like ligand-binding oxidase (R2lox) protein is...
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