Article

The neuropeptide alpha calcitonin gene-related peptide impairs load-stimulated proteoglycan production of human chondrocytes via WNT activity

2024-10-13

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Novel targets for osteoarthritis therapy are urgently needed, and sensory nerve fibres and their neuropeptides are increasingly recognised for their contribution to structural aspects of joint pathology. The nociceptive sensory neuropeptide alpha calcitonin gene-related peptide (αCGRP) was previously detected in synovial fluid and serum of osteoarthritis patients and was also...

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Literature Corpus work: 1d400565-fbbe-5426-b8c1-840c22c3a351
DOI: 10.1101/2024.10.11.617807

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