Article
Unloading results in rapid loss of TGFβ signaling in articular cartilage: role of loading-induced TGFβ signaling in maintenance of articular chondrocyte phenotype?
Osteoarthritis and cartilage - 1 Oct 2016
Madej W, van Caam A, Blaney Davidson E, Buma P, van der Kraan P M
Abstract excerpt
OBJECTIVE: Recently it was shown that loading of articular cartilage explants activates TGFβ signaling. Here we investigated if in vivo chondrocytes express permanently high TGFβ signaling, and the consequence of the loss of compressive loading-mediated TGFβ signaling on chondrocyte function and phenotype. METHOD: Bovine articular cartilage explants were collected within 10 min post mortem and stained immediately...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.