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Molecular Mechanism Study of Medial Open-Wedge High Tibial Osteotomy in Treating Medial Compartment Osteoarthritis of the Knee by Improving the Intra-Articular Environment

2025-11-13

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Medial compartment osteoarthritis (MCOA) of the knee, often linked to varus malalignment, leads to increased medial tibiofemoral stress, accelerating cartilage degradation and inflammation. Medial open-wedge high tibial osteotomy (MOWHTO) corrects this alignment to relieve symptoms, but its molecular and biomechanical mechanisms are underexplored. <bold>Hypo...

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Literature Corpus work: f2989b13-d290-58a9-ab57-aa82e66b82d3
DOI: 10.21203/rs.3.rs-7918672/v1

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