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Article

SH3 domains with high affinity and engineered ligand specificities targeted to HIV-1 Nef.

Journal of molecular biology - 12 Nov 1999

Hiipakka M, Poikonen K, Saksela K

Abstract excerpt

The avid binding of HIV-1 Nef to the Src homology-3 (SH3) domain of Hck (KD 250 nM) has been shown to involve an interaction between the RT-loop of Hck-SH3 and residues in Nef outside of its prototypic polyproline type II (PPII) helix-containing SH3-ligand region. Such distinctive interactions are thought to provide specificity and affinity for other SH3/ligand protein complexes as well. Here, we have constructed...

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Source

Identifiers

PMID: 10547288
DOI: 10.1006/jmbi.1999.3225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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