Article

Chronic α-Synuclein Over-Expression and Ceruloplasmin Challenge Promote Distinct Iron and Redox Responses in M17 Cells

2026-06-16

Abstract excerpt

<h4>Background</h4> While α-synuclein (α-syn) accumulation and iron dysregulation are hallmarks of Parkinson’s Disease, the adaptations that enable neuronal survival under chronic protein stress remain unclear. Here, we investigated how α-syn overexpression and ceruloplasmin (Cp)-mediated iron modulation alters iron and redox homeostasis. <h4>Methods</h4> We utilized human BE(2)-M17 neuroblastoma cell lines stab...

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Literature Corpus work: 919c0ae6-f4eb-57f5-b10b-d102628ec62d
DOI: 10.64898/2026.06.15.732494

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