Article

STAT3-mediated ferroptosis is involved in α-synuclein pathology

2023-05-11

Abstract excerpt

<h4>Background: </h4> Oligomeric α-synuclein (α-syn) can activate microglia to drive the early stages of Parkinson's disease (PD) pathogenesis. Our previous studies have found a significant expression difference between the lncRNA IL6ST-AS and its antisense RNA IL6ST in the cerebrospinal fluid of PD patients. Furthermore, in α-syn-induced HMC3 cells, a decline in IL6ST and its downstream target JAK2/STAT3 were als...

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Literature Corpus work: f8ee683d-ae89-502b-8a8b-04d269f579c0
DOI: 10.21203/rs.3.rs-2906594/v1

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