Article

α-syn overexpression, NRF2 suppression, and enhanced ferroptosis create a vicious cycle of neuronal loss in Parkinson’s disease

2022-07-23

Abstract excerpt

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, affecting millions each year. Most PD cases (∼90%) are sporadic, resulting from the age-dependent accumulation of pathogenic effects. One key pathological hallmark of PD progression is the accumulation of alpha-synuclein (α-syn), which has been shown to negatively affect neuronal function and viability. Here, using 3- and 6-month-old N...

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Literature Corpus work: 3bc9ad61-d36a-5f17-8366-7a140fedf772
DOI: 10.1101/2022.07.22.501183

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