Article

Copper-containing ROS-scavenging nanozyme paradoxically drives α-synucleinopathy by amplifying nitrosative stress

2025-07-05

Abstract excerpt

Reactive oxygen and nitrogen species (RONS) are implicated in neurodegeneration, but their specific pathogenic roles remain unclear. Here, we developed a pair of iridium-based nanozymes with opposing functionalities to dissect these pathways. We show that a copper-tuned iridium nanozyme (Ir□Cu), despite being a superior ROS scavenger, paradoxically and dramatically exacerbated α-synuclein (αSyn) pathology in vivo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3ef16fd7-803e-53a4-aba3-86e0574cb220
DOI: 10.1101/2025.07.01.661317

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Copper-containing ROS-scavenging nanozyme paradoxically drives α-synucleinopathy by amplifying nitrosative stressDOI 10.1101/2025.07.01.661317Read

From cell death to neurological disease: Unraveling the role of copperSemantic proximity Read

A Dual-Function Guanidinium Scaffold that Couples Copper Sequestration with Redox Protection in Wilson diseaseSemantic proximity Read

Repurposing Melatonin in dual-mode for Wilson disease therapy as a Copper Chelator and an antioxidant agentSemantic proximity Read

Copper: From enigma to therapeutic target for neurological disorderSemantic proximity Read

Nanozymes for Non-neoplastic Diseases: Catalytic Therapy RedefinedSemantic proximity Read

Dissecting the copper bioinorganic chemistry of the functional and pathological roles of the prion protein: Relevance in Alzheimer's disease and cancerSemantic proximity Read

Chronic α-Synuclein Over-Expression and Ceruloplasmin Challenge Promote Distinct Iron and Redox Responses in M17 CellsSemantic proximity Read

The <i>SNCA</i> A53T mutation sensitizes human neurons and microglia to ferroptosisSemantic proximity Read

The Gasotransmitter Trio (NO, CO, H₂S) in Cardiovascular Health and Disease: From Molecular Crosstalk to Precision Gas MedicineSemantic proximity Read

The synucleins are a family of redox-active copper binding proteins.Semantic proximity Read

Mutant superoxide dismutase 1-catalyzed hydrogen therapy for amyotrophic lateral sclerosis achieved by intercepting oxidative stress-neuroinflammation crosstalk.Semantic proximity Read

Sodium Thiosulfate: An Innovative Multi-Target Repurposed Treatment Strategy for Late-Onset Alzheimer’s DiseaseSemantic proximity Read