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Article

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2000

Ostrerova-Golts N, Petrucelli L, Hardy J, Lee J M, Farer M, Wolozin B

Abstract excerpt

Parkinson's disease (PD) is the most common motor disorder affecting the elderly. PD is characterized by the formation of Lewy bodies and death of dopaminergic neurons. The mechanisms underlying PD are unknown, but the discoveries that mutations in alpha-synuclein can cause familial PD and that alpha-synuclein accumulates in Lewy bodies suggest that alpha-synuclein participates in the pathophysiology of PD. Using...

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PMID: 10934254
PMCID: PMC6772599

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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