Article

Pan-cancer analysis of tumor mutational burden and homologous recombination DNA damage repair by targeted next-generation sequencing

2020-08-03

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Current variability in methods for tumor mutational burden (TMB) estimation and reporting urges the need for a homogeneous TMB assessment. Here we compared the TMB distributions in different cancer types using two customized targeted panels commonly used in clinical practice. <bold>Methods: </bold>TMB spectrum of the 295- and 1021-Gene panels in multiple cancer...

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Literature Corpus work: 91950433-78fe-5602-abe1-d8db00d5df92
DOI: 10.21203/rs.3.rs-49293/v1

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