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Pan-cancer Analysis of Tumor Mutational Burden and Homologous Recombination DNA Damage Repair Using Targeted Next-Generation Sequencing.

Cancer research and treatment - 1 Oct 2021

Wang Hai-Yun, Deng Ling, Li Ying-Qing, Zhang Xiao, Long Ya-Kang, Zhang Xu, Feng Yan-Fen, He Yuan, Tang Tao, Yang Xin-Hua, Wang Fang

Abstract excerpt

PURPOSE: Current variability in methods for tumor mutational burden (TMB) estimation and reporting demonstrates the urgent need for a homogeneous TMB assessment approach. Here, we compared TMB distributions in different cancer types using two customized targeted panels commonly used in clinical practice. MATERIALS AND METHODS: TMB spectra of 295- and 1021-gene panels in multiple cancer types were compared using...

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Identifiers

PMID: 33677848
DOI: 10.4143/crt.2020.798
PMCID: PMC8524032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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