Article
Pan-cancer analysis reveals homologous recombination deficiency score as a predictive marker for immunotherapy responders.
Human cell - 1 Jan 2022
Yang Can, Zhang Zijing, Tang Xuemei, Zhang Xinju, Chen Yuming, Hu Tingting, Zhang Huating, Guan Ming, Zhang Xiuming, Wu Zhiyuan
Abstract excerpt
The immune context of the tumor microenvironment (TME) is critical for effective immunotherapy. Nonetheless, DNA-based biomarkers for the immune-sensitive TME and the identification of immune checkpoint inhibitor (ICI) responders are under-explored. This study aims to comprehensively landscape the homologous recombination deficiency (HRD) score, an emerging hallmark for tumor genome instability that triggers...
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