Article

Cancer cell survival depends on collagen uptake into tumor-associated stroma

2022-04-05

Abstract excerpt

<title>Abstract</title> <p>Collagen I, the most abundant protein in humans, is ubiquitous in solid tumors where it provides a rich source of exploitable metabolic fuel for cancer cells. While tumor cells were unable to exploit collagen directly, here we show they can usurp metabolic byproducts of collagen-consuming tumor-associated stroma. Using genetically engineered mouse models, we discovered that solid tumor...

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Literature Corpus work: 918c81cd-4ae4-52cc-b034-d3482ffd5d4d
DOI: 10.21203/rs.3.rs-1451724/v1

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