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Article

Collagens in Cancer: Structural Regulators and Guardians of Cancer Progression

13 Jan 2023

Abstract excerpt

Collagen is one of the most abundant proteins in animals and a major component of the extracellular matrix (ECM) in tissues. Besides playing a role as a structural building block of tissues, collagens can modulate the behavior of cells, and their deregulation can promote diseases such as cancer. In tumors, collagens and many other ECM molecules are mainly produced by fibroblasts, and recent evidence points toward...

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PMID: 36638361
DOI: 10.1158/0008-5472.can-22-2034

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