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Collagens and Cancer associated fibroblasts in the reactive stroma and its relation to Cancer biology

6 Mar 2019

Abstract excerpt

The extracellular matrix (ECM) plays an important role in cancer progression. It can be divided into the basement membrane (BM) that supports epithelial/endothelial cell behavior and the interstitial matrix (IM) that supports the underlying stromal compartment. The major components of the ECM are the collagens. While breaching of the BM and turnover of e.g. type IV collagen, is a well described part of...

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PMID: 30841909
DOI: 10.1186/s13046-019-1110-6

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