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Acquired resistance to immune checkpoint inhibitors is associated with hypoxia and ECM remodeling in colorectal cancer

2026-04-29

Abstract excerpt

Acquired resistance to immune checkpoint inhibitors (ICIs) limits the durability of therapeutic responses across multiple cancer types, yet the underlying mechanisms remain poorly defined. Using the murine MC38 colorectal cancer model, we established an in vivo model recapitulating clinical response patterns, including complete regression, primary resistance, and acquired resistance. Tumors with acquired resistanc...

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Literature Corpus work
6f993d99-a03f-52ba-802c-3bd9d8d9e0a1
DOI
10.64898/2026.04.27.720591
Open publication

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Acquired resistance to immune checkpoint inhibitors is associated with hypoxia and ECM remodeling in colorectal cancerDOI 10.64898/2026.04.27.720591
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