Article

Nutrient availability-driven changes in extracellular matrix biochemical and mechanical properties regulate pancreatic cancer cell biology

2025-09-21

Abstract excerpt

The extracellular matrix (ECM) provides key biochemical and biomechanical cues that govern fundamental cellular processes, including growth and migration. ECM dysregulation and altered cell-matrix interactions are a driver of cancer progression, exemplified by pancreatic ductal adenocarcinoma (PDAC), where an abnormally dense, collagen-rich, and stiff ECM correlates with poor patient outcomes. The PDAC microenviro...

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Literature Corpus work: 9f7e2cb7-c7e3-5aaf-a227-babb276d7b4e
DOI: 10.1101/2025.09.21.677637

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