Article

Extracellular SPON2 Protein Inhibits Metabolism by Blocking Glutamine Uptake to Coordinate Mammary Morphogenesis and Cancer Suppression

2026-07-15

Abstract excerpt

<title>Abstract</title> <p>Tissue morphogenesis and tumor progression are governed by reciprocal interactions between epithelial cells and their microenvironment, yet how epithelial niches regulate metabolic fitness during development and cancer remains poorly understood. Here, we identify SPON2 as a basal-derived extracellular protein that functions as a metabolic checkpoint during mammary gland morphogenesis an...

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Literature Corpus work: 8c69e118-31b9-5c35-8d25-ab70273045a9
DOI: 10.21203/rs.3.rs-10069476/v1

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Extracellular SPON2 Protein Inhibits Metabolism by Blocking Glutamine Uptake to Coordinate Mammary Morphogenesis and Cancer SuppressionDOI 10.21203/rs.3.rs-10069476/v1Read

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