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Article

Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61

29 Mar 2016

Abstract excerpt

Apratoxin A is a natural product with potent antiproliferative activity against many human cancer cell lines. However, we and other investigators observed that it has a narrow therapeutic window in vivo Previous mechanistic studies have suggested its involvement in the secretory pathway as well as the process of chaperone-mediated autophagy. Still the link between the biologic activities of apratoxin A and its in...

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PMID: 27196783
DOI: 10.1158/1535-7163.mct-15-0648

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