Article

AI-Based Discovery and CryoEM Structural Elucidation of a K <sub>ATP</sub> Channel Pharmacochaperone

2024-09-05

Abstract excerpt

Pancreatic K ATP channel trafficking defects underlie congenital hyperinsulinism (CHI) cases unresponsive to the K ATP channel opener diazoxide, the mainstay medical therapy for CHI. Current clinically used K ATP channel inhibitors have been shown to act as pharmacochaperones and restore surface expression of trafficking mutants; however, their therapeutic utility for K ATP trafficking impaired CHI is hindered...

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Literature Corpus work: f617689f-1568-5183-ab1b-62d191c990f8
DOI: 10.1101/2024.09.05.611490

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