Back to search

Article

Single-Cell RNA Sequencing Reveals the Altered Landscape of Immune Cells in Immune Checkpoint Inhibitor Related Myocarditis

2022-01-27

Abstract excerpt

<h4>Background</h4> Myocarditis has emerged as a rare but lethal Immune checkpoint inhibitor (ICI)-associated toxicity. However, the exact mechanism for ICI related myocarditis remains underexplored; and the specific therapeutic targets is still lacking. In this study, we used scRNA-seq to characterize the transcriptomic profiles of single cells from the peripheral blood mononuclear cell (PBMC) of ICI related myoc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
3ded1a86-26af-5564-9cc9-6133dc3dce26
DOI
10.1101/2022.01.21.22269639
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Single-Cell RNA Sequencing Reveals the Altered Landscape of Immune Cells in Immune Checkpoint Inhibitor Related MyocarditisDOI 10.1101/2022.01.21.22269639
Single‐cell RNA sequencing reveals the altered innate immunity in immune checkpoint inhibitor‐related myocarditisSemantic proximity
Single-cell transcriptomic analysis deciphers the inflammatory microenvironment characterized by CXCL9+ fibroblasts and ACKR1+ endothelial cells in immune-related myocarditisSemantic proximity
Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor–Induced MyocarditisSemantic proximity
Molecular pathways and cellular subsets associated with adverse clinical outcomes in overlapping immune-related myocarditis and myositisSemantic proximity
Deciphering Immune Complexity: Single-Cell Insights into Autoimmune Myocarditis ProgressionSemantic proximity
Single-Cell Multi-Omics Identifies Specialized Cytotoxic and Migratory CD8 + Effector T Cells in Acute MyocarditisSemantic proximity
Dissecting the cellular landscape and transcriptome network in viral myocarditis by single-cell RNA sequencingSemantic proximity
A Novel Therapeutic Approach using CXCR3 Blockade to Treat Immune Checkpoint Inhibitor-mediated MyocarditisSemantic proximity
Utilizing Single-cell RNA Sequencing for Analyzing the Characteristics of PBMC in Patients with Kawasaki DiseaseSemantic proximity
Dysregulated CD4+ T Cells and microRNAs in MyocarditisSemantic proximity
Comprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathySemantic proximity
Deciphering Cell-Type-Specific Gene Expression Signatures of Cardiac Diseases Through Reconstruction of Bulk TranscriptomesSemantic proximity
Select a neighboring publication to make it the new centre.