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Article

TCR β-Chain Sharing in Human CD8+ T Cell Responses to Cytomegalovirus and EBV

1 Dec 2008

Abstract excerpt

The CD8(+) TCR repertoires specific for many immunogenic epitopes of CMV and EBV are dominated by a few TCR clonotypes and involve public TCRs that are shared between many MHC-matched individuals. In previous studies, we demonstrated that the observed sharing of epitope-specific TCRbeta chains between individuals is strongly associated with TCRbeta production frequency, and that a process of convergent...

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Share to Cytomegalovirus and herpesvirus research
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PMID: 19017975
DOI: 10.4049/jimmunol.181.11.7853

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