Article

Integration of ζ-deficient CARs into the <i>CD3-zeta</i> gene conveys potent cytotoxicity in T and NK cells

2023-11-14

Abstract excerpt

I. Chimeric antigen receptor (CAR)-reprogrammed immune cells hold significant therapeutic potential for oncology, autoimmune diseases, transplant medicine, and infections. All approved CAR-T therapies rely on personalized manufacturing using undirected viral gene transfer, which results in non-physiological regulation of CAR-signaling and limits their accessibility due to logistical challenges, high costs and bios...

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Literature Corpus work: 91490f07-142a-5d17-a136-89f8fc574953
DOI: 10.1101/2023.11.10.565518

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