Article

Are entirely virus-free CAR T cells as good as lentiviral transduced universal cells?

2026-05-02

Abstract excerpt

Chimeric Antigen Receptor (CAR) T cells are now established as therapies for some haematological malignancies. While lentiviral or γ-retroviral vectors are commonly used for CAR delivery due to their efficiency and stable integration, supply constraints have created bottlenecks to wider applications and access. Alternatively, genome editing tools such as CRISPR-Cas9 can insert CAR genes by homology-directed repair...

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Literature Corpus work: 8afa5840-56c1-5af3-a625-e28340c3a511
DOI: 10.64898/2026.04.30.721956

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