Article

Engineering CD3 Subunits with Endoplasmic Reticulum Retention Signal Facilitates Allogeneic CAR T Cell Production

2024-09-24

Abstract excerpt

The success of autologous CAR T cell therapies has driven interest in developing off-the-shelf allogeneic CAR T cells as a scalable and readily available option for broader patient access. Most of the current approaches involve the knockout of T cell receptor (TCR) subunits via genome editing for preventing graft-versus-host disease (GvHD). However, clinical translation of these methods faces challenges due to man...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3cfffecf-3df9-5e98-ab39-44ac545cca58
DOI: 10.1101/2024.09.22.614328

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Engineering CD3 Subunits with Endoplasmic Reticulum Retention Signal Facilitates Allogeneic CAR T Cell ProductionDOI 10.1101/2024.09.22.614328Read

Gene editing of CD3 epsilon to redirect regulatory T cells for adoptive T cell transferSemantic proximity Read

Integration of ζ-deficient CARs into the CD3 ζ gene conveys potent cytotoxicity in T and NK cellsSemantic proximity Read

Integration of ζ-deficient CARs into the <i>CD3-zeta</i> gene conveys potent cytotoxicity in T and NK cellsSemantic proximity Read

Unlocking the potential of Tregs: innovations in CAR technologySemantic proximity Read

Allogeneic CAR-T Cells: Engineering Around Host ImmunitySemantic proximity Read

Miniaturized CAR knocked onto CD3ε extends TCR function with CAR specificity under control of endogenous TCR signaling cascadeSemantic proximity Read

Gene editing of <i>CD3 epsilon</i> gene to redirect regulatory T cells for adoptive T cell transferSemantic proximity Read

Automated GMP-Compatible Production of Universal CAR Tregs for Organ-Targeted Tolerance InductionSemantic proximity Read

Off-the-Shelf Chimeric Antigen Receptor T CellsSemantic proximity Read

Engineering better chimeric antigen receptor T cellsSemantic proximity Read

Safety switch optimization enhances antibody-mediated elimination of CAR T cellsSemantic proximity Read

Engineering and Design of Chimeric Antigen ReceptorsSemantic proximity Read