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Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

2 May 2012

Abstract excerpt

The success of adoptive T cell gene transfer for treatment of cancer and HIV is predicated on generating a response that is both durable and safe. We report long-term results from three clinical trials to evaluate gammaretroviral vector-engineered T cells for HIV. The vector encoded a chimeric antigen receptor (CAR) composed of CD4 linked to the CD3ζ signaling chain (CD4ζ). CAR T cells were detected in 98% of...

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PMID: 22553251
DOI: 10.1126/scitranslmed.3003761

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