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Article

MyosinA is a druggable target in the widespread protozoan parasite Toxoplasma gondii.

PLoS biology - 1 May 2023

Kelsen Anne, Kent Robyn S, Snyder Anne K, Wehri Eddie, Bishop Stephen J, Stadler Rachel V, Powell Cameron, Martorelli di Genova Bruno, Rompikuntal Pramod K, Boulanger Martin J, Warshaw David M, Westwood Nicholas J, Schaletzky Julia, Ward Gary E

Abstract excerpt

Toxoplasma gondii is a widespread apicomplexan parasite that can cause severe disease in its human hosts. The ability of T. gondii and other apicomplexan parasites to invade into, egress from, and move between cells of the hosts they infect is critical to parasite virulence and disease progression. An unusual and highly conserved parasite myosin motor (TgMyoA) plays a central role in T. gondii motility. The goal...

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PMID: 37155705
DOI: 10.1371/journal.pbio.3002110
PMCID: PMC10185354

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MyosinA is a druggable target in the widespread protozoan parasite Toxoplasma gondii.PMID 37155705Read ↗

The class XIV myosin of <i>Toxoplasma gondii</i> , TgMyoA, is druggable in an animal model of infectionSemantic proximity Read ↗

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Phosphorylation of a Myosin Motor by TgCDPK3 Facilitates Rapid Initiation of Motility during Toxoplasma gondii egressSemantic proximity Read ↗

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