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Article

Yeast three-hybrid screen identifies TgBRADIN/GRA24 as a negative regulator of Toxoplasma gondii bradyzoite differentiation.

PloS one - 1 Jan 2015

Odell Anahi V, Tran Fanny, Foderaro Jenna E, Poupart Séverine, Pathak Ravi, Westwood Nicholas J, Ward Gary E

Abstract excerpt

Differentiation of the protozoan parasite Toxoplasma gondii into its latent bradyzoite stage is a key event in the parasite's life cycle. Compound 2 is an imidazopyridine that was previously shown to inhibit the parasite lytic cycle, in part through inhibition of parasite cGMP-dependent protein kinase. We show here that Compound 2 can also enhance parasite differentiation, and we use yeast three-hybrid analysis...

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Identifiers

PMID: 25789621
DOI: 10.1371/journal.pone.0120331
PMCID: PMC4366382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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