Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Evidence for Cytochrome b Q i Site Inhibition by 4(1 H )-Quinolone-3-Diarylethers and Antimycin in Toxoplasma gondii

6 Dec 2016

Abstract excerpt

ABSTRACT Toxoplasma gondii is an apicomplexan parasite that causes fatal and debilitating brain and eye disease. Endochinlike quinolones (ELQs) are preclinical compounds that are efficacious against apicomplexan-caused diseases, including toxoplasmosis, malaria, and babesiosis. Of the ELQs, ELQ-316 has demonstrated the greatest efficacy against acute and chronic experimental toxoplasmosis. Although genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Parasitic Infections and Diagnostics
Share to Pneumocystis jirovecii pneumonia detection and treatment
Share to Toxoplasma gondii Research Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27919897
DOI: 10.1128/aac.01866-16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Evidence for Cytochrome b Q i Site Inhibition by 4(1 H )-Quinolone-3-Diarylethers and Antimycin in Toxoplasma gondiiPMID 27919897Read ↗

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infectionsSemantic proximity Read ↗

Subtle changes in endochin-like quinolone structure alter the site of inhibition within the cytochrome bc1 complex of Plasmodium falciparum.Semantic proximity Read ↗

Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease.Semantic proximity Read ↗

Cytochrome b mutation identified in a decoquinate-resistant mutant of Toxoplasma gondii.Semantic proximity Read ↗

A Theileria annulata parasite with a single mutation, methionine 128 to isoleucine (M128I), in cytochrome B is resistant to buparvaquone.Semantic proximity Read ↗

Characterization of cytochrome b from Toxoplasma gondii and Q(o) domain mutations as a mechanism of atovaquone-resistance.Semantic proximity Read ↗

Stereospecific Resistance to N2-Acyl Tetrahydro-β-carboline Antimalarials Is Mediated by a PfMDR1 Mutation That Confers Collateral Drug SensitivitySemantic proximity Read ↗

Chemical genetics of Plasmodium falciparum.Semantic proximity Read ↗

Structure-based therapeutic development against the Apicomplexan parasitesSemantic proximity Read ↗

Effective Therapy Targeting Cytochrome bc 1 Prevents Babesia Erythrocytic Development and Protects from Lethal InfectionSemantic proximity Read ↗

Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors.Semantic proximity Read ↗

Therapeutics development against the Apicomplexa parasites Plasmodium falciparum and Toxoplasma gondiiSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.