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Article

Cancer cell cycle heterogeneity as a critical determinant of therapeutic resistance

14 Jan 2023

Abstract excerpt

Intra-tumor heterogeneity is now arguably one of the most-studied topics in tumor biology, as it represents a major obstacle to effective cancer treatment. Since tumor cells are highly diverse at genetic, epigenetic, and phenotypic levels, intra-tumor heterogeneity can be assumed as an important contributing factor to the nullification of chemotherapeutic effects, and recurrence of the tumor. Based on the role of...

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PMID: 37588236
DOI: 10.1016/j.gendis.2022.11.025

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