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Article

Addressing intra-tumoral heterogeneity and therapy resistance.

Oncotarget - 1 Nov 2016

Rybinski Brad, Yun Kyuson

Abstract excerpt

In the last several years, our appreciation of intra-tumoral heterogeneity has greatly increased due to accumulating evidence for the co-existence of genetically and epigenetically divergent cancer cells residing in different microenvironments within a tumor. Herein, we review recent literature discussing intra-tumoral heterogeneity in the context of therapy resistance mechanisms at the genetic, epigenetic and...

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Share to Antineoplastic Agents
Share to Drug Resistance, Neoplasm
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Molecular Targeted Therapy

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Source

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Identifiers

PMID: 27608848
DOI: 10.18632/oncotarget.11875
PMCID: PMC5342165

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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